Impact of Obesity on Cancer Survivorship and the Potential Relevance of Race and Ethnicity
Identifieur interne : 003572 ( Main/Exploration ); précédent : 003571; suivant : 003573Impact of Obesity on Cancer Survivorship and the Potential Relevance of Race and Ethnicity
Auteurs : Kathryn H. Schmitz ; Marian L. Neuhouser ; Tanya Agurs-Collins ; Krista A. Zanetti ; Lisa Cadmus-Bertram ; Lorraine T. Dean ; Bettina F. DrakeSource :
- JNCI Journal of the National Cancer Institute [ 0027-8874 ] ; 2013.
Descripteurs français
- KwdFr :
- Comorbidité, Facteurs de risque, Fatigue (étiologie), Groupes ethniques (), Humains, Indice de masse corporelle, Lymphoedème (étiologie), Neuropathies périphériques (étiologie), Obésité (), Obésité (ethnologie), Obésité (épidémiologie), Populations d'origine continentale (), Qualité de vie, Résultat thérapeutique, Survie sans rechute, Taux de survie, Tumeurs (), Tumeurs (ethnologie), Tumeurs (mortalité), Tumeurs (étiologie), Tumeurs du sein (), État de santé.
- MESH :
- ethnologie : Obésité, Tumeurs.
- mortalité : Tumeurs.
- épidémiologie : Obésité.
- étiologie : Fatigue, Lymphoedème, Neuropathies périphériques, Tumeurs.
- Comorbidité, Facteurs de risque, Groupes ethniques, Humains, Indice de masse corporelle, Obésité, Populations d'origine continentale, Qualité de vie, Résultat thérapeutique, Survie sans rechute, Taux de survie, Tumeurs, Tumeurs du sein, État de santé.
English descriptors
- KwdEn :
- Body Mass Index, Breast Neoplasms (complications), Breast Neoplasms (prevention & control), Comorbidity, Continental Population Groups (statistics & numerical data), Disease-Free Survival, Ethnic Groups (statistics & numerical data), Fatigue (etiology), Health Status, Humans, Lymphedema (etiology), Neoplasms (complications), Neoplasms (ethnology), Neoplasms (etiology), Neoplasms (mortality), Neoplasms (prevention & control), Neoplasms (therapy), Obesity (complications), Obesity (epidemiology), Obesity (ethnology), Peripheral Nervous System Diseases (etiology), Quality of Life, Risk Factors, Survival Rate, Treatment Outcome.
- MESH :
- complications : Breast Neoplasms, Neoplasms, Obesity.
- epidemiology : Obesity.
- ethnology : Neoplasms, Obesity.
- etiology : Fatigue, Lymphedema, Neoplasms, Peripheral Nervous System Diseases.
- mortality : Neoplasms.
- prevention & control : Breast Neoplasms, Neoplasms.
- statistics & numerical data : Continental Population Groups, Ethnic Groups.
- therapy : Neoplasms.
- Body Mass Index, Comorbidity, Disease-Free Survival, Health Status, Humans, Quality of Life, Risk Factors, Survival Rate, Treatment Outcome.
Abstract
Evidence that obesity is associated with cancer incidence and mortality is compelling. By contrast, the role of obesity in cancer survival is less well understood. There is inconsistent support for the role of obesity in breast cancer survival, and evidence for other tumor sites is scant. The variability in findings may be due in part to comorbidities associated with obesity itself rather than with cancer, but it is also possible that obesity creates a physiological setting that meaningfully alters cancer treatment efficacy. In addition, the effects of obesity at diagnosis may be distinct from the effects of weight change after diagnosis. Obesity and related comorbid conditions may also increase risk for common adverse treatment effects, including breast cancer–related lymphedema, fatigue, poor health–related quality of life, and worse functional health. Racial and ethnic groups with worse cancer survival outcomes are also the groups for whom obesity and related comorbidities are more prevalent, but findings from the few studies that have addressed these complexities are inconsistent. We outline a broad theoretical framework for future research to clarify the specifics of the biological–social–environmental feedback loop for the combined and independent contributions of race, comorbid conditions, and obesity on cancer survival and adverse treatment effects. If upstream issues related to comorbidities, race, and ethnicity partly explain the purported link between obesity and cancer survival outcomes, these factors should be among those on which interventions are focused to reduce the burden of cancer.
Url:
DOI: 10.1093/jnci/djt223
PubMed: 23990667
PubMed Central: 3776266
Affiliations:
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Le document en format XML
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Schmitz</name></author><author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L." last="Neuhouser">Marian L. Neuhouser</name></author><author><name sortKey="Agurs Collins, Tanya" sort="Agurs Collins, Tanya" uniqKey="Agurs Collins T" first="Tanya" last="Agurs-Collins">Tanya Agurs-Collins</name></author><author><name sortKey="Zanetti, Krista A" sort="Zanetti, Krista A" uniqKey="Zanetti K" first="Krista A." last="Zanetti">Krista A. Zanetti</name></author><author><name sortKey="Cadmus Bertram, Lisa" sort="Cadmus Bertram, Lisa" uniqKey="Cadmus Bertram L" first="Lisa" last="Cadmus-Bertram">Lisa Cadmus-Bertram</name></author><author><name sortKey="Dean, Lorraine T" sort="Dean, Lorraine T" uniqKey="Dean L" first="Lorraine T." last="Dean">Lorraine T. Dean</name></author><author><name sortKey="Drake, Bettina F" sort="Drake, Bettina F" uniqKey="Drake B" first="Bettina F." last="Drake">Bettina F. Drake</name></author></analytic><series><title level="j">JNCI Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Body Mass Index</term><term>Breast Neoplasms (complications)</term><term>Breast Neoplasms (prevention & control)</term><term>Comorbidity</term><term>Continental Population Groups (statistics & numerical data)</term><term>Disease-Free Survival</term><term>Ethnic Groups (statistics & numerical data)</term><term>Fatigue (etiology)</term><term>Health Status</term><term>Humans</term><term>Lymphedema (etiology)</term><term>Neoplasms (complications)</term><term>Neoplasms (ethnology)</term><term>Neoplasms (etiology)</term><term>Neoplasms (mortality)</term><term>Neoplasms (prevention & control)</term><term>Neoplasms (therapy)</term><term>Obesity (complications)</term><term>Obesity (epidemiology)</term><term>Obesity (ethnology)</term><term>Peripheral Nervous System Diseases (etiology)</term><term>Quality of Life</term><term>Risk Factors</term><term>Survival Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Comorbidité</term><term>Facteurs de risque</term><term>Fatigue (étiologie)</term><term>Groupes ethniques ()</term><term>Humains</term><term>Indice de masse corporelle</term><term>Lymphoedème (étiologie)</term><term>Neuropathies périphériques (étiologie)</term><term>Obésité ()</term><term>Obésité (ethnologie)</term><term>Obésité (épidémiologie)</term><term>Populations d'origine continentale ()</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Survie sans rechute</term><term>Taux de survie</term><term>Tumeurs ()</term><term>Tumeurs (ethnologie)</term><term>Tumeurs (mortalité)</term><term>Tumeurs (étiologie)</term><term>Tumeurs du sein ()</term><term>État de santé</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term><term>Neoplasms</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="ethnologie" xml:lang="fr"><term>Obésité</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="ethnology" xml:lang="en"><term>Neoplasms</term><term>Obesity</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fatigue</term><term>Lymphedema</term><term>Neoplasms</term><term>Peripheral Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Breast Neoplasms</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Continental Population Groups</term><term>Ethnic Groups</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Obésité</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Fatigue</term><term>Lymphoedème</term><term>Neuropathies périphériques</term><term>Tumeurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Body Mass Index</term><term>Comorbidity</term><term>Disease-Free Survival</term><term>Health Status</term><term>Humans</term><term>Quality of Life</term><term>Risk Factors</term><term>Survival Rate</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Comorbidité</term><term>Facteurs de risque</term><term>Groupes ethniques</term><term>Humains</term><term>Indice de masse corporelle</term><term>Obésité</term><term>Populations d'origine continentale</term><term>Qualité de vie</term><term>Résultat thérapeutique</term><term>Survie sans rechute</term><term>Taux de survie</term><term>Tumeurs</term><term>Tumeurs du sein</term><term>État de santé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Evidence that obesity is associated with cancer incidence and mortality is compelling. By contrast, the role of obesity in cancer survival is less well understood. There is inconsistent support for the role of obesity in breast cancer survival, and evidence for other tumor sites is scant. The variability in findings may be due in part to comorbidities associated with obesity itself rather than with cancer, but it is also possible that obesity creates a physiological setting that meaningfully alters cancer treatment efficacy. In addition, the effects of obesity at diagnosis may be distinct from the effects of weight change after diagnosis. Obesity and related comorbid conditions may also increase risk for common adverse treatment effects, including breast cancer–related lymphedema, fatigue, poor health–related quality of life, and worse functional health. Racial and ethnic groups with worse cancer survival outcomes are also the groups for whom obesity and related comorbidities are more prevalent, but findings from the few studies that have addressed these complexities are inconsistent. We outline a broad theoretical framework for future research to clarify the specifics of the biological–social–environmental feedback loop for the combined and independent contributions of race, comorbid conditions, and obesity on cancer survival and adverse treatment effects. If upstream issues related to comorbidities, race, and ethnicity partly explain the purported link between obesity and cancer survival outcomes, these factors should be among those on which interventions are focused to reduce the burden of cancer.</p></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Agurs Collins, Tanya" sort="Agurs Collins, Tanya" uniqKey="Agurs Collins T" first="Tanya" last="Agurs-Collins">Tanya Agurs-Collins</name><name sortKey="Cadmus Bertram, Lisa" sort="Cadmus Bertram, Lisa" uniqKey="Cadmus Bertram L" first="Lisa" last="Cadmus-Bertram">Lisa Cadmus-Bertram</name><name sortKey="Dean, Lorraine T" sort="Dean, Lorraine T" uniqKey="Dean L" first="Lorraine T." last="Dean">Lorraine T. Dean</name><name sortKey="Drake, Bettina F" sort="Drake, Bettina F" uniqKey="Drake B" first="Bettina F." last="Drake">Bettina F. Drake</name><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L." last="Neuhouser">Marian L. Neuhouser</name><name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name><name sortKey="Zanetti, Krista A" sort="Zanetti, Krista A" uniqKey="Zanetti K" first="Krista A." last="Zanetti">Krista A. Zanetti</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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